Grandium Hotel Prague

A New Town five-star five minutes from the main station

Hours: Check-in 15:00-24:00, check-out by 11:00 (official site)
Per night (approx.): 약 €80~263 (약 1,950~6,410 Kč)
Address: Politických vězňů 12, New Town, Prague 1, one block off the upper end of Wenceslas Square

A big hotel on the avenue between the top of Wenceslas Square and the main station. The airport bus stops at the station, five-odd minutes away on foot, which makes arrival and departure days easy, and Old Town Square is 10-15 minutes' walk. Rooms are clean and modern in honey, white and grey, and the breakfast with a made-to-order omelette station gets praised in review after review. For a five-star it's not hard on the wallet, which is why reviews pile up here.